Jennie Leach, Department of Chemical, Biochemical & Environmental Engineering
Marilyn Allen, Department of Chemical, Biochemical & Environmental Engineering
Gregory Szeto, Allen Institute of Immunology
Violeta Rus, University of Maryland School of Medicine
Profiling the gene expression of early and late-stage female BALB/c pristane-induced mice using RNASeq in blood and peritoneal exudate cells identifies similarities with clinical SLE by comparing the transcriptomes of pristane-induced mice with publicly available human datasets and datasets from alternative mouse models. Gene and pathway signatures will be used to subtype and classify different manifestations of disease. This will more precisely define the utility of the pristane-induced mouse model as a model system for SLE therapeutics.