Developing near-infrared phosphorescent probes for biomedical applications
Dr. Marcin Ptaszzek, Department of Chemistry & Biochemistry.
Codi Hrynko, Department of Chemistry & Biochemistry.
Phosphorescent probes are promising agents for a variety of biomedical applications. Developing on novel, near-infrared phosphorescent probes requires through understanding of photophysics and excited-state dynamics in target molecules. In this project we will perform calculations of photophysical properties relevant to phosphorescence (such as triplet state energies, rates of intersystem crossing and phosphorescence rate constants), for a series of tetrapyrrolic macrocycles. Computations will contribute to understanding structure-phosphorescence properties relationship and allow for developing brightly phosphorescent probes for in vivo applications.