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Molecular modeling of effects of phosphorylation on proteins

Dr. Lasse Lindahl, Faculty, Biology
Dr. Ian Thorpe, Faculty, Chemistry
Dr. Bruce Johnson, Faculty, Chemistry
Nusrat Rahman, Grad Student, Biology

 

Post-translational modifications, like phosphorylation, acetylation, affects a proteins charge, hydrophobicity, which results in changes in the protein’s conformation, binding properties etc. The project will use molecular simulation tools (eg. Gromacs) to simulate effect of phosphorylation of ribosomal protein L5 on its binding to 5S rRNA.